With the rollout of the new Cuda drivers, it looks like the Fermi based video cards are now rendered obsolete.

http://docs.nvidia.com/cuda/cuda-toolkit-release-notes/index.html

Deprecated Features:

•Fermi Architecture Support. Fermi architecture support is being deprecated in the CUDA 8.0 Toolkit, which will be the last toolkit release to support it. Future versions of the CUDA Toolkit will not support the architecture and are not guaranteed to work on that platform. Note that support for Fermi is being deprecated in the CUDA Toolkit but not in the driver. Applications compiled with CUDA 8.0 or older will continue to work on Fermi with newer NVIDIA drivers.

If this is true, then it needs to be officially announced as it will affect many users. I knew this day would be coming, just hoping it would be delayed a little bit longer.

Have a look at this thread - especially this post

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Thanks for the reference. I have already retired my old GTX 570 with a new GTX 1070. Wow, What a difference! Much more efficient power wise and tasks finish in hours instead of days now!

I run three dedicated machines. One of them has a 9600 GT and two GT 310s. They will only support up to the 340 drivers. Granted they are not very fast, but aside from the 9600 which was given to me, they only use 30 watts each and only cost $12 each.

So regardless of the task turnaround time they are very power efficient and the replacement cost is minimal. So unless you are crunching on the same machine you are gaming on there is no point in spending over $100 on a 10 series card.

I run three dedicated machines. One of them has a 9600 GT and two GT 310s. They will only support up to the 340 drivers. Granted they are not very fast, but aside from the 9600 which was given to me, they only use 30 watts each and only cost $12 each.

So regardless of the task turnaround time they are very power efficient and the replacement cost is minimal. So unless you are crunching on the same machine you are gaming on there is no point in spending over $100 on a 10 series card.

It may be that you can barely see the energy cost of those little cards on your bill ... but I beg to differ in regard to efficiency ... compare the GT310 with the new GT1030, they have about the same TDP.

The new 1030 is 20x (!!) times faster in regard to SP GFLOPS and therefore 20 times more efficient. Put it another way, the 1030 requires 1,5 Watt for the same performance. Whereas the old GT310 pulls 30W.

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I would love to see HCF1 protein folding and interaction simulations to help my little boy... someday.

Should a GTX750Ti be considered obsolete?

Why I am asking this?

As already explained in other threads, since the implementation of the new crunching software acemd 918.80 in April, my GTX750Ti in the Windows10 host (WDDM overhead!) has tremendous problems when crunching such demanding tasks like
..._crystal_ss_contacts_50_ubiquitin_... and ..._crystal_ss_contacts_100_ubiquitin_...
and sometimes also
...PABLO_all_data_goal_KIX_CMYB-...

What does the problem look like? All of a sudden, crunchings stops, and does not continue until the task is suspended and resumed in the BOINC manager. Even if not overclocked at all!
BTW, I have read about this behaviour also in other threads here in the forum, so it's definitely NOT a defect of the card itself.

If this happens some time during the night, or even during daytime when I am not at home and noticing what's going on, the task runs idle for several hours. Which, of course, makes no sense.
Recently, such a task stopped 7 or 8 times in the course of 3 days.

I had already proposed to the GPUGRID people, here in the forum, to introduce a third type of task for these ones mentioned above, called "very long runs" or similar (besides the current "long runs" and the "short runs" which don't seem to exist any longer). However, no reaction so far, and I doubt that there will be any.
Another way to fix this might of course be to repair the buggy crunching software. However, this doesn't happen either :-(

Whereas my other GTX750Ti which runs in the Windows XP host has none of these problems, although overclocked markedly (also, the crunching software is a different one: acemd 849.65).

So, in short: must a GTX750ti in a Windows10 system be considered obsolete? At least what concerns GPUGRID crunching?
Would be interesting what happens when crunching Folding@Home.

I just ordered a computer with a AMD Radeon (TM) RX 580 with 8GB GDDR5 Graphics Memory. Will this work for GPUGrid?

AMD Radeon (TM) RX 580

to my knowledge, only NVIDIA works with GPUGRID

I just ordered a computer with a AMD Radeon (TM) RX 580 with 8GB GDDR5 Graphics Memory. Will this work for GPUGrid?

No, it won't work with GPUGrid.
Take a look at the apps page. There are only CUDA and CPU (multi-thread) clients present.
CUDA is NVidia's own proprietary GPU programming language.